ECTO-1 if full of electronic aviation components. Accoring to Stephen Dane “When I was working on Blade Runner, I went out to the Tucson airplane wrecking area and came back with two forty-foot flatbeds full of aircraft junk, and that sensibility showed up in Ghostbusters.” True indeed. He definitely had an assortment of things to sort through. Stephen said that he got things off the shelf that looked good at the moment, and that he made a career out of “visual bull”. He only had two weeks to come up with the Ectomobile and all the other props for the movie. Stephen Dane, credited as a ‘Hardware Consultant’, designed and oversaw the development of the original ECTO-1. (The picture above shows how the Ectomobile ECTO-1 looked when first purchased)īefore I get to far, I want to recognize the designer and creator of ECTO-1. STEPHEN DANE – DESIGNED AND OVERSAW DEVELOPMENT OF ECTO-1 Notice how the red on the side of ECTO-1 is encased in chrome trim? The louvers on the back door are not original. The 1959 Cadillac Eureka ambulance / hearse had a rear side window that sloped down, and a rear corner window that sloped up. Notice how the window frame at the back corner on this 1959 Cadillac Superior ambulance / hearse angles (yellow arrow).īoth the 1959 Cadillac S&S (Hess & Eisenhardt) and 1959 Cadillac Barnett coaches do not have rear corner windows. Look at how the window trim is straight around the side and rear corner of the body. So just because it’s a 1959 Cadillac doesn’t mean it’s the right car. There were several companies that built ambulances and hearses on Cadillac’s Professional Chassis. There is said to only have been 400 1959 Cadillac Miller-Meteor’s built. (The real Ghostbusters 1959 Cadillac Miller Meteor Futura Ectomobile) The Futura models have wrap around windows in the rear. The cars used in the Ghostbusters (1984) and Ghostbusters II (1989) is a 1959 Cadillac Miller-Meteor Futura Duplex (hearse / ambulance combination). 1959 CADILLAC MILLER-METEOR FUTURA DUPLEX: Not only is it cool, but it’s clearly not an attempt to recreate the original Ghostbusters car, so there’s no reason for die hard fans to be critical of the details. In this case, the person that built the vehicle decided to build the vehicle they felt the Ghostbusters would drive today. More specifically, ECTO-1A had a satellite dish and black and yellow stripes on the side. This car appears to be a mix of ECTO-1 from Ghostbusters and ECTO-1A from Ghostbusters II. That said, some of the coolest Ectomobiles have been built out of modern vehicles. If you’re going to do it, then go all in all the way and try to make it look like a legitimate Ghostbusters vehicle. Personally I go in to things with a ride or die attitude. I get that there’s simply the fun in making your own version of the Ectomobile. I find that people can be pretty critical if you get any of the details wrong. Some of the parts are hard to find, and some people recreate them on their own. Since Ghostbusters first showed up on film over 35 years ago, people have been attempting to recreate the ECTO-1 Ectomobile.
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] Exhausted T cells could be defined by sustained expression of inhibitory receptors ( CTLA‐4, PD‐1, TIGIT, LAG3, TIM3). The efficacy of many checkpoint inhibitors largely depends on their ability to reduce CD8 + cytotoxic T cells in the microenvironment, whose cytotoxic ability may be rendered inactive by reaching a T cell dysfunction state called exhaustion. Because the immune microenvironment is highly complex, evaluation of clinical outcome requires deep understanding of the T cells underlying the leukemia. ] Whether the properties of the host immune system affect disease risk or outcome in leukemia is unknown. Therefore, deepening the understanding of inhibition states and the functional heterogeneity of T cells in patients will be paramount to revealing new therapeutic targets.Ĭurrently, prognostic factors for leukemias depend on their risk stratification, including the genomic features of leukemia cells and clinical characteristics, for example, age, the count of white blood cell (WBC) at diagnosis, and response to chemotherapy. ] For instance, the efficacies of CAR‐T cell therapy are not uniform among patients and closely related to the activity of derived T cells. ] Furthermore, it is increasingly appreciated that the immune microenvironment governs the strength of the anticancer response following immune therapies. ] T cells with chimeric antigen receptors (CARs) have led to impressive responses and encouraging outcomes in patients with hematological malignancies. Over the past decade, immune‐based approaches such as monoclonal antibody therapy and checkpoint inhibitor therapy have emerged. Therefore, new strategies using fewer toxic elements are urgently needed. ] Current chemotherapies aim at killing abnormal leukemia cells while inevitably damaging normal cells and carrying significant risk of long‐term toxicities. ] Although most patients initially respond to chemotherapy, ≈60% relapse, and only 30% survive within 5 years thus, overall anti‐tumor responses remain limited. Together, these data provide for the first‐time valuable insights for understanding exhausted T cell populations in leukemia.ī cell‐acute lymphoblastic leukemia (B‐ALL) is a clonal hematopoietic disease characterized by the abnormal proliferation and accumulation of B‐lymphoid progenitor cells. Coupled with single‐cell T cell receptor repertoire profiling, diverse originations of the exhausted T cells in B‐ALL are suggested, and clonally expanded exhausted T cells are likely to originate from CD8 + effector memory/terminal effector cells. Of note, these exhausted T cells possess remarkable heterogeneity, and ten sub‐clusters are further identified, which are characterized by different cell cycle phases, naïve states, and GNLY (coding granulysin) expression. Two exhausted T cell populations, characterized by up‐regulation of TIGIT, PDCD1, HLADRA, LAG3, and CTLA4 are specifically discovered in B‐ALL patients. All 11 major T cell subsets in healthy individuals are found in the patients with B‐ALL, with the counterparts in the patients universally showing more activated characteristics. Unbiased bioinformatics analysis enabled the authors to identify 13 T cell clusters in the patients based on their molecular properties. Here, single‐cell RNA sequencing is performed with T cells sorted from the peripheral blood of healthy individuals and patients with B cell‐acute lymphoblastic leukemia (B‐ALL). Characterization of functional T cell clusters is key to developing strategies for immunotherapy and predicting clinical responses in leukemia. We are a flawless mixture of the maker, wholesalers, and exporters international and are pleasant non for our absolute gold, silver, and diamond enhancements studded with precious, semi-precious stones and treasured gemstones. In like manner, we have assured that at “Silvesto India (P) Ltd.” you have simple price preferences and several different installment alternatives so that our clients do not want to confront any troubles managing us. In addition to jewelry, we additionally provide our consumers’ choice of Gold plated jewelry at a very low-priced price. 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You can use it to run airtable-export in order to back up your Airtable data to a GitHub repository. GitHub Actions is GitHub's workflow automation product. airtable-export export base_id table1 table2 -key=key -http-read-timeout 60 You can override the timeout during a network read operation using the -http-read-timeout option. You can override the user-agent using the -user-agent option: airtable-export export base_id table1 table2 -key=key -user-agent "Airtable Export Robot" Request optionsīy default the tool uses python-httpx's default configurations. If you run this command against an existing SQLite database records with matching primary keys will be over-written by new records from the export. Those tables will have a primary key column called airtable_id. The SQLite database will have a table created for each table you export. If you only specify -sqlite the export directory argument will be ignored. This can be combined with other format options. You can export tables to a SQLite database file using the -sqlite database.db option: airtable-export export base_id table1 table2 \ ndjson file for each exported table: airtable-export export base_id table1 table2 \ You can pass multiple format options at once. You can also export as JSON or as newline delimited JSON using the -json or -ndjson options: airtable-export export base_id table1 table2 -key=key -ndjson Export optionsīy default the tool exports your data as YAML. Rather than passing the API key using the -key option you can set it as an environment variable called AIRTABLE_KEY. This example would create two files: export/table1.yml and export/table2.yml. You can export all of your data to a folder called export/ by running the following: airtable-export export base_id table1 table2 -key=key The names of each of the tables that you wish to export.Your Airtable API key - this is a string starting with key.Your Airtable base ID - this is a string starting with app.You will need to know the following information: Install this tool using pip: $ pip install airtable-export Export Airtable data to files on disk Installation Regular expressions use special characters in the PATTERN string to match a wider array of strings. (That's what the "re" in "grep" stands for). The true power of grep is that it can match regular expressions. Using regular expressions to perform more powerful searches Notice that the directory name is included for any matching files that are not in the current directory. Let's change our FILE name to an asterisk (" *"), so that it matches any file or directory name, and not only HTML files: We can extend our search to subdirectories and any files they contain using the -r option, which tells grep to perform its search recursively. Notice that each line starts with the specific file where that match occurs. When the command is executed, the shell expands the asterisk to the name of any file it finds (in the current directory) which ends in ". Instead of specifying product-listing.html, we can use an asterisk (" *") and the. If we have multiple files to search, we can search them all using a wildcard in our FILE name. Searching multiple files using a wildcard Using the -i option, grep finds a match on line 23 as well. What if "our products" appears at the beginning of a sentence, or appears in all uppercase? We can specify the -i option to perform a case-insensitive match: Performing case-insensitive grep searches Our matching line is prefixed with " 18:" which tells us this corresponds to line 18 in our file. If we specify the -n option, grep will prefix each matching line with the line number: It will be even more useful if we know where the matching line appears in our file. Viewing line numbers of successful matches If we use the -color option, our successful matches will be highlighted for us: For more information, see: Regular expression quick reference. Other characters have special meanings, however - some punctuation marks, for example. In the above example, all the characters we used (letters and a space) are interpreted literally in regular expressions, so only the exact phrase will be matched. The PATTERN is interpreted by grep as a regular expression. Openjdk-11-doc/bionic-updates,bionic-updates,bionic-security,bionic-security 10.0.2+13-1ubuntu0.18.04.2 all Let’s explore which other packages we have at our disposal besides the default jdk package: $ apt list openjdk-11* Listing. Let’s have a look at the “Depends” section of the output. We can see that if we inspect the package: $ apt show openjdk-11-jdk It’s also worth noting that although the package is called openjdk-11-jdk, as of this writing, it actually installs version 10.0.2. Now we should see the same version number as shown above: javac 1.8.0_181 3.2. Let’s check that the javac executable is available as well: $ javac -version OpenJDK 64-Bit Server VM (build 25.181-b13, mixed mode) The result should list a Runtime Environment and a JVM: openjdk version "1.8.0_181" Now, let’s verify the installation: $ java -version Let’s install OpenJDK 8 from the “Main” repository with apt: $ sudo apt update It’s supported by Canonical - the same company that maintains Ubuntu itself. The “Main” repository is available by default on all Ubuntu systems. Of course, we can also head to the OpenJDK website, grab a package there, and install it the same way we’ve seen in the previous section.īut using the apt tooling and the “Main” repository provides some benefits. For this reason, we can find an up-to-date version of OpenJDK 8 in the “Main” repository on most of the supported Ubuntu versions. JDK 8 is an LTS version that has been around for a while. Shanahan discusses a study in which 95% of ingredients listed as “natural flavor” contained MSG.Īs for “natural” flavor, it could even be secretions from a beaver’s butt. In Food Rules: A Doctor’s Guide To Healthy Eating, Dr. Hell, even monosodium glutamate (MSG) can be masquerading as a natural flavor. I take issue with anything listed as “natural flavors.” Because chances are, it’s not all that natural. Garcinia cambogia is not recommended for anyone with liver issues, pregnant, breastfeeding, on certain pain or psychiatric medications. Garcinia cambogia, even without obvious side effects like liver failure, may still cause negative effects on the body and liver in particular, such as elevated liver enzymes. In 2017 the FDA warned the public to stop using a popular product containing garcinia cambogia due to it causing liver complications. In fact, garcinia cambogia contains hydroxycitric acid, an ingredients banned by the FDA in 2009 for causing liver failure. When we block this pathway, we are setting ourselves up for nutrient deficiencies, gut issues, hormone imbalances, a weakened immune system and so much more. Hunger is the body’s way of signaling to the brain that it needs more nutrients. Let me make something very clear: hunger is normal. GC is said to block fat and decrease appetite. Upset stomach or worsened irritable bowel syndrome.This is not how to effectively, safely lose weight. While Green Coffee Bean Extract (GCBE) is not inherently unhealthy, it is not something anyone should be taking regularly or long-term. Let’s look at the ingredients used in Plexus products: Green Coffee Bean Extract It is clearly targeted at people who frustrated with their (probably unsustainable) diet program, on the lookout for an “easy fix”. Guys, it is just another MLM (like Herbalife, ItWorks!, Arbonne, etc.) who markets supplements as the key to overall fitness, beauty and wellness.Įspecially popular, Plexus Slim ( the so-called pink drink), a product for those who think that some powder/shake/magif pill will help them lose weight. So what is Plexus? Plexus sells weight loss supplements manufactured by the network marketing company Plexus Worldwide Inc. We don’t eat whole foods anymore, and now we turn to supplements with sketchy ingredients designed to squash our hunger signals? This is not health. What concerns me about products like Plexus is how far we have come from real, natural food. But I am at least thankful that the company has cleaned up the ingredient list. And while they still sort of are, the ingredient list has admittedly improved a bit.ĭon’t get me wrong – I still do not support or recommend these products. Use code 10OFF for 10% off! An unbiased review of Plexusīack when I wrote this original review, Plexus was using incredibly dangerous stimulants linked to serious side effects. Aka a healthy gut, glowing skin, strong digestion and energy for DAYS. I drink it in my daily smoothies and it gives me LIFE. Grass-fed collagen with six organic superfoods: kale, spirulina, wheatgrass, broccoli, spinach and turmeric. I couldn’t find one good enough on the market, so I made my own. Is Plexus safe? Is it worth your money and will it help you lose weight? Find out below in an unbiased review of Plexus! 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When you buy a brand new amp on amazon for less than an authorized dealer gets it for directly from Rockford, that should be a giant red flag. They're ok as long as you know you're getting the real deal and not a Chinese knockoff. r/electricvehicles - For electric vehicles r/diyaudio - Audio Projects & talk For the DIY'er r/soundsystem - PA's, Concert Rigs, Road Gear r/hometheater - For the HomeTheater lovers r/audiophile - Strictly High Fidelity discussion r/CarAVvendors - CarAV vendor info/deals r/CarAVclassifieds - CarAV's trading hub Please remember to restrict product promotion posts to 10% or less of your total combined self and link posts as per reddit spam guidelines. Vendors, please use this area to introduce yourselves, submit reddit-related discounts and sales, and occasionally promote new product lines. Or join the rest of the reddit Audio Network in our channel on freenode, #redditaudio!Ī subreddit for helping new enthusiasts get up and running with recommended system buildouts.Ī subreddit specifically for vendors, reddit promotions, and introductions. Requests made without using this feature will be ignored. Use the modmail link located directly above the mod list for all mod-related questions and concerns. It will help you get ideas for your new system. Recommendations Formīrowse through the CarAV Approved Gear list - a list of products that were hand-picked by our knowledgeable community. Use the Recommendations Form to get advice from our community of enthusiasts in order to help you choose a system. Q&A, Advice, Tips, tricks and tech welcome! New to CarAV?Ĭonsult the sidebar, the growing wiki or search the sub before asking questions. |
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